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Steam-In-Place Connectors

Steam-in-Place (SIP) Connectors

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Create a sterile link between pre-sterilized bag systems or tube sets and stainless process equipment with CPC Steam-Thru^® Connections (STC). Steam-Thru SIP Connectors offer an innovative three-port design that maximizes sterility assurance by eliminating “dead legs” and allowing steam to pass directly through the connection to “steam on” to stainless equipment.

With a “steam on” and “steam off” capability, STC II Steam-in-Place (SIP) Connectors deliver a sterile connection and sterile disconnection without the need for a laminar flow hood. Steam-Thru II Connectors reduce the potential of microbial contamination of the process flow path, as well as environmental contamination within manufacturing facilities.

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Benefits of CPC Steam-Thru Connectors

Broad range of valve and shutoff terminations to meet mounting and flow requirements
Pre-sterilized by gamma irradiation up to 50 KiloGrays or autoclaved up to 129°C for 60 minutes
Innovative three-port design providing a SIP process, eliminating “dead legs” and need for laminar flow hoods
Thumb latch and tear-away sleeve to secure valve position and provides visual indicator of process stage
Industry standard terminations that speed connection to the process equipment and connect to popular flexible tubing sizes
ADCF-free material that meet BSE/TSE requirements

Integrated AseptiQuik^® Sterile Connectors with Steam-Thru SIP Connectors

For maximum design flexibility, AseptiQuik  STC Connectors integrate an AseptiQuik Sterile Connector with a  Steam-Thru II SIP Connector for increased flexibility between hybrid stainless steel and single-use processing equipment. Biopharma processing and manufacturing engineers can choose AseptiQuik STC Connectors with genderless design (AseptiQuik G Series or AseptiQuik S Series) or incorporate a keyed female-to-male connection (AseptiQuik C Series), depending on configuration at the aseptic connector end.

Processes and Applications Where CPC Steam-Thru Connectors Fit

Single-use assemblies
Steam-In-Place (SIP) applications
Sterile transfer of liquids
Connection to single-use containers and stainless-steel systems
Multi-use to single-use connection

The union of the two connectors into a single unit through a sanitary clamp allows an AseptiQuik sterile connection to be steamed onto stainless equipment via SIP. After the SIP cycle, a wide range of single-use systems can be connected. The SIP process can be done in advance allowing a quick and easy sterile connection to the AseptiQuik Connector half without having to wait 30-60 minutes for SIP prior to harvest.

Benefits of CPC AseptiQuik Sterile Connectors with Steam-Thru Connections

Increased flexibility when using hybrid stainless steel and single-use processing equipment
Mount directly to stainless steel processing equipment via a sanitary termination
Genderless design or keyed female-to-male connection at the aseptic connector end
Simple 3-step connection process that reduces operator error
Patented valve design for sterile connections and disconnections to stainless equipment
Sanitary interface between two sterile connectors for a more secure connection than tubing with ties
Allows the SIP process to be done in advance allowing a quick and easy sterile connection to the AseptiQuik Sterile Connector half without having to wait 30-60 minutes for SIP prior to harvest

Best Practices and How To Videos

Steam-Thru Connections from CPC

Learn how the CPC Steam-Thru Connector's innovative design allows media to be safely transferred without the cleaning and validation concerns associated with reusable components.

Steam-Thru Connections II from CPC

See how CPC Steam-Thru® II Connections' innovative design allows a quick and easy sterile connection between biopharmaceutical processing equipment and disposable bag and tube assemblies.

How to Assemble Steam-Thru Connector from CPC

See the quick and easy way to create a sterile connection between stainless steel processing equipment and single-use systems for steam-in-place sterilization process.

How to Assemble Steam-Thru II Connector from CPC

The quick and easy way to create a sterile connection between stainless steel processing equipment and single-use systems for steam-in-place sterilization process. The STC II offers the flexibility of steam-on and steam-off functionality.

Steam-Thru Connectors Best Practice for Proper Use

Your quick reference for optimal performance of your steam-in place sterilization process. The best practices include eliminating external force or side load; ensure proper alignment; make sure there is no residual pressure during actuation; and to not us

Sterile Connectors

Easy-to-use AseptiQuik® and MicroCNX® Connectors provide quick and sterile connections, even in non-sterile environments—a critical capability for your biopharmaceutical manufacturing.